Functional Plasticity in the Substrate Binding Site of β-Secretase
نویسندگان
چکیده
منابع مشابه
Functional Plasticity in the Substrate Binding Site of -Secretase
The aspartic protease -secretase (BACE) cleaves the amyloid precursor protein into a 42 residue -peptide, which is the principal biochemical marker of Alzheimer’s disease. Multiple explicit-water molecular dynamics simulations of the apo and inhibitor bound structures of BACE indicate that both openand closed-flap conformations are accessible at room temperature and should be taken into account...
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15 صفحه اولComputational Insights into Substrate and Site Specificities, Catalytic Mechanism, and Protonation States of the Catalytic Asp Dyad of β-Secretase
In this review, information regarding substrate and site specificities, catalytic mechanism, and protonation states of the catalytic Asp dyad of β-secretase (BACE1) derived from computational studies has been discussed. BACE1 catalyzes the rate-limiting step in the generation of Alzheimer amyloid beta peptide through the proteolytic cleavage of the amyloid precursor protein. Due to its biologic...
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ژورنال
عنوان ژورنال: Structure
سال: 2005
ISSN: 0969-2126
DOI: 10.1016/j.str.2005.06.015